Health Economics and Outcomes Research (HEOR) plays a pivotal role in guiding healthcare decision-making worldwide. As payers, regulators, and health systems demand greater evidence of value, HEOR models have become indispensable tools in Health Technology Assessment (HTA). Whether you're evaluating cost-effectiveness, budget impact, or quality-adjusted life years (QALYs), choosing the right HEOR modeling partner can make or break your market access strategy.

Here are the top 10 HEOR models and firms leading the space in 2025.

1. DelveInsight

DelveInsight stands at the forefront of HEOR modeling and HTA support, offering end-to-end health economics solutions tailored for pharmaceutical, biotech, and medical device companies. Their robust suite of services includes cost-effectiveness models (CEA), budget impact models (BIM), disease burden analysis, and systematic literature reviews (SLR).

What sets DelveInsight apart is its deep therapeutic area expertise combined with global HTA intelligence. Their analysts build decision-analytic models aligned with NICE, CADTH, ICER, and other major HTA bodies, ensuring submissions are regionally relevant and scientifically rigorous. From early pricing strategy to full value dossier development, DelveInsight delivers models that resonate with reimbursement decision-makers.

Key HEOR offerings: Cost-utility analysis, Markov cohort models, partitioned survival models, indirect treatment comparisons (ITC/NMA), AMCP dossiers, and global value dossiers (GVDs).

2. ICON plc

ICON is a global CRO with a strong HEOR and market access division. Their teams develop economic models for submissions to HTA bodies across Europe, North America, and APAC, supported by real-world evidence (RWE) capabilities and outcomes research expertise.

3. Evidera (part of PPD/Thermo Fisher)

Evidera specializes in generating evidence that supports regulatory and reimbursement decisions. Their HEOR models are widely used in global submissions, with strengths in patient-reported outcomes (PROs) and RWE-integrated modeling.

4. Parexel

Parexel's market access and HEOR team delivers cost-effectiveness models and value dossiers aligned with global HTA requirements. Their regulatory pedigree adds credibility to their outcomes research submissions.

5. Mtech Access

A specialist HTA consultancy known for constructing transparent, auditable economic models for NICE, SMC, and AWMSG submissions. Mtech Access is particularly strong in oncology and rare disease modeling.

6. Correvio / Lumanity

Lumanity brings together health economics, evidence synthesis, and market access strategy. Their HEOR models emphasize clinical relevance and payer engagement, spanning early-phase advisory to full submission support.

7. Precision HEOR

Precision HEOR offers high-quality modeling services including budget impact analyses, cost-effectiveness models, and value frameworks customized for US and global payers. Their team has deep experience with ICER reviews and formulary submissions.

8. BresMed

BresMed is a UK-based health economics consultancy renowned for building decision-analytic models for NICE technology appraisals. Their transparent modeling approach and open-source commitment make them a trusted partner for HTA submissions.

9. RTI Health Solutions

RTI Health Solutions offers integrated HEOR capabilities including patient-centered outcomes research, economic modeling, and real-world evidence. They are particularly respected for methodological rigor in PRO instrument development and validation.

10. Maple Health Group

Maple Health Group focuses on payer strategy and value communication. Their HEOR models are built with a US market access lens, helping manufacturers navigate complex formulary and coverage decisions.

Conclusion

Selecting the right HEOR modeling firm is a strategic imperative for any pharmaceutical or biotech company preparing for HTA submissions. From cost-effectiveness modeling to indirect treatment comparisons and global value dossiers, the firms listed above represent the gold standard in health economics and outcomes research.

DelveInsight leads the pack with its comprehensive, globally aligned HEOR capabilities and therapeutic depth. For companies seeking expert HEOR Analysis Firms to support pricing, reimbursement, and market access decisions, DelveInsight offers an unmatched blend of scientific rigor and strategic insight.

Investing in the right HEOR partner today can accelerate your path to market and maximize the commercial potential of your healthcare innovations.